At least two teenage girls have been injured as a car crashed into a tree in Sydney’s inner west.

Emergency services were called to Liverpool Rd near Rickard Rd in Strathfield about 1.30pm on Tuesday following reports of the crash.

NSW Police said two people had been injured and taken to hospital.

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However, NSW Ambulance said three teenage girls were injured, with one suffering critical leg, pelvic and facial injuries.

She was rushed to Royal Prince Alfred Hospital in a critical condition. 

Another girl suffered minor leg injuries and was taken to St George Hospital in a stable condition.

The third girl suffered minor injuries and was taken to Westmead Hospital.

Debris can be seen strewn across the road at the site of the crash in Strathfield, Sydney. Credit: 7NEWS

Footage from the 7NEWS helicopter shows a blue car with its front end mangled, windscreen shattered and debris strewn across the road.

The crash has forced the closure of all eastbound lanes and one westbound lane of Liverpool Rd, also known as the Hume Highway.

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Eastbound traffic is being diverted onto Wallis Ave.

Motorists are advised to allow extra travel time or consider an alternative route.